▼11%
$154,445
Avg. Base Salary (USD)
/ year
Avg. Base Salary (USD)
10%
$134k
MEDIAN
$154k
90%
$183k
The average salary for a Principal Scientist is $154,445 in 2025
Base Salary
$134k - $183k
Bonus
$14k - $45k
Total Pay
$145k - $217k
Is Average Experienced Principal Scientist Salary in San Francisco, California your job title? Find out what you should be paid
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What is the Pay by Experience Level for Principal Scientists?
What Do Principal Scientists Do?
Find your market worth – how it works:
Common Health Benefits for a Principal Scientist
Medical
100%
Dental
88%
Vision
75%
Gender Breakdown for Principal Scientists
Male
60.0%
Female
40.0%
This data is based on 5 survey responses. Learn more about the gender pay gap.
FAQs About Principal Scientists
What is the highest pay for Principal Scientists in San Francisco?
Our data indicates that the highest pay for a Principal Scientist in San Francisco is $183k / year
What is the lowest pay for Principal Scientists in San Francisco?
Our data indicates that the lowest pay for a Principal Scientist in San Francisco is $134k / year
How can Principal Scientists increase their salary?
Increasing your pay as a Principal Scientist is possible in different ways. Change of employer: Consider a career move to a new employer that is willing to pay higher for your skills. Level of Education: Gaining advanced degrees may allow this role to increase their income potential and qualify for promotions. Managing Experience: If you are a Principal Scientist that oversees more junior Principal Scientists, this experience can increase the likelihood to earn more.